A CHEMICAL-GENETIC STRATEGY REVEALS DISTINCT TEMPORAL REQUIREMENTS FOR SAD-1 KINASE IN NEURONAL POLARIZATION AND SYNAPSE FORMATION

A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation

Abstract Background Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation.In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is essential for proper neuronal polarity and synaptic organization.To determine if SAD-1 activity regulates the establishment

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